Original Research and Translational Studies

Reports of new experimental, computational or clinically relevant cancer research should present a defined question, reproducible methods and evidence supporting the conclusions. Use a structured abstract covering Background, Methods, Results and Conclusions, followed by Introduction, Methods, Results and Discussion. Translational studies should explain the connection between the biological findings and the proposed diagnostic or therapeutic application, with appropriate validation.

Reviews

Narrative reviews should provide a critical synthesis of a clearly defined topic rather than a catalogue of studies. Explain the basis for selecting the literature, address conflicting evidence and distinguish established knowledge from speculation. Use an unstructured abstract and a logically organized main text. Unsolicited reviews are considered on the same editorial basis as invited reviews.

Systematic Reviews and Meta-analyses

Evidence syntheses should state the research question, eligibility criteria, complete search strategy and search dates, selection process, risk-of-bias assessment and synthesis methods. Report protocol registration when applicable, explain deviations and submit a PRISMA checklist and flow diagram. Meta-analyses require justified effect measures, assessment of heterogeneity and sensitivity analyses appropriate to the available evidence.

Methodological Papers

Methods articles should describe an advance relevant to cancer investigation, including validation against appropriate comparators and a realistic account of limitations. Supply sufficient procedural detail, code, reagent information or accessible protocols for independent use. A technical description without evidence of performance or scientific utility is generally insufficient.

Perspectives

Selected perspectives discuss a significant scientific question, emerging approach or unresolved issue in cancer biology or therapeutics. They should develop a clear argument grounded in the literature, identify uncertainties and avoid unsupported clinical recommendations. An invitation does not exempt a contribution from editorial or ethical assessment.

Length and supporting materials

Length should be proportionate to the study and article type. The journal does not impose a single word limit across all categories; authors should prioritize complete reporting and concise interpretation. Supplementary files may contain detailed protocols, additional analyses and supporting datasets, but essential evidence must remain accessible in the main article. A case-based or unusual article format should be discussed with the Editorial Office before submission.